Research and CV

U Bin Kim, Ph. D.

Ubin has a broad interest in all aspects of organic chemistry, with expertise spanning total synthesis, catalysis, process development, and medicinal chemistry. Ubin has contributed to the field through book chapters, review articles, patents, and original research publications. With experience in both academic and industrial settings, Ubin has led process and medicinal chemistry teams, working on the development of Kinase inhibitors and complex APIs such as Eribulin, Relugolix, and Lenvatinib. Most recently, Ubin transitioned to a role at MFC, where he oversees CMO/CDMO projects ranging from process chemistry to early-stage drug discovery.

Birth details: South Korea (1986), 38 years old.

Nationality: New Zealand

E-mail: ubinkim@gmail.com

Language: English (fluent, first language); Korean (oral, fluent)

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2024 - current: Principal Research Engineer (수석연구원) / Global business development

MFC (엠에프씨)
Gwacheon, South Korea

2020 - 2024: Senior Researcher (책임연구원) / Project Leader / Team Leader

YS Life Science (Yonsung fine chemicals)
Suwon, South Korea

2019 - 2020: Senior Researcher (선임연구원) / Project Leader / Team Leader

VoronoiBio
Songdo, Incheon, South Korea Collapse

2015-2018: Postdoctoral Associate

Ewha W. University
Advisor: Professor Sang-gi Lee
Seoul, South Korea

2009-2014: Ph. D. (download PhD thesis here)

University of Auckland
Advisor: Professor Margaret A. Brimble
Auckland, New Zealand

2008: BSc (Honours) 1st Class. (download BSc Hons. thesis here)

University of Auckland
Advisor: Professor Margaret A. Brimble

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Industry
Process Chemistry
Proprietary Synthesis of the C27-C35 Fragment of Eribulin and it’s Elaboration Towards the C14-C35 Sub-unit.
Kim, U B.; Samala, S.; Jung, J.; Song, J.; Lee, K-Y.; Oh, C-Y.; Shin, H. Org. Process Res. Dev., 2024, 28, 2832–2843.
DOI: acs.oprd.4c00150 | [pdf] | [preview]

Process Chemistry
Scalable synthesis of the C14-C23 fragment of Eribulin and Halichondrin B.
Kim, U B.1; Samala, S.1; Kim, N.; Bogonda, G.; Lago-Santome, H.; Jeong, Y.; Kim, J.; Jung, J.; Jeon, S-H.; Lee, S. J.; Shin, H. Bull. Korean. Chem. Soc., 2022, 43, 1367. (1 = Equal contribution)
DOI: 10.1002/bkcs.12624 | [pdf] | [preview]

Process Chemistry
Synthesis of the C1–C13 Fragment of Eribulin on a Kilogram Scale.
Kim, S. T.; Park, Y.; Kim, N.; Gu, J.; Son, W.; Hur, J.; Lee, K.; Baek, A.; Song, J. Y.; Kim, U B.; Lee, K-Y.; Oh, C-Y.; Park, S.; Shin, H. Org. Process. Res. Dev., 2022, 26, 123.
DOI: 10.1021/acs.oprd.1c00295 | [pdf] | [preview]

Process Chemistry
Process Development of Tacalcitol.
Lee, S. J.; Moon, H. W.; Lee, K-Y.; Oh, C. Y.; Kim, U B.; Shin, H. Org. Process. Res. Dev., 2021, 25, 982.
DOI: 10.1021/acs.oprd.1c00010 | [pdf] | [preview]

Medicinal Chemistry
Heteroaryl derivatives, and it’s pharmaceutical composition for use in preventing cancer containing the same as an active ingredient.
Kim, U B.; Lee, Y. H.; Kang, S-i, Hwnag, S. A.; Kim, D. M.; Kim, S. S.; Jung, M. H.; Kim, H. K.; Jung, H. R.; Kim, Y. S.; Jang, H. J.; Choi, J. E.; Lee, S. H.; Son, J. B., Kim, N. D.
[Patent filed] PCT/KR2020/003558. March, 13, 2020 | [pdf] | [preview]

Post-Doc work
Catalysis, Review
Synergistic Dual Transition Metal Catalysis.
Kim, U B.; Jung, D. J.; Jeon, H. J.; Rathwell, K.; Lee, S.-g. Chem. Rev., 2020, 120, 13382-13433.
DOI: 10.1021/acs.chemrev.0c00245 | [pdf] | [preview]

Catalysis, Book Chapter
Rhodium/Palladium Dual Catalysis.
Kim, U B.; Lee, S.-g. Science of Synthesis. 2019, 1, 57
[Book Chapter, Ed.: Molander, G. A.] DOI: 10.1055/sos-SD-231-00029

Catalysis
Palladium-Catalyzed Divergent Cyclopropanation by Regioselective Solvent-Driven C(sp3)-H Bond Activation.
Chung, D. S.; Lee, J. S.; Ryu, H.; Park, J.; Kim, H.; Lee, J. H., Kim, U B..; Lee, W. K.; Baik, M.-H.*; Lee, S.-g.
Angew. Chem. Int. Ed., 2018, 57, 15460-15464.
DOI: 10.1002/anie.201809133 | [pdf] | [preview]

Catalysis
Rh(II)/Mg(OtBu)2‑Catalyzed Tandem One-Pot Synthesis of 1,4-Oxazepines and 1,4-Oxazines from N‑Sulfonyl-1,2,3-triazoles and Glycidols.
Ko, Y. O.; Jeon, H. J.; Jung, D. J.; Kim, U B.; Lee, S.-g. Org. Lett., 2016, 18, 6432-6435.
DOI: 10.1021/acs.orglett.6b03328 | [pdf] | [preview]

Methodology
Synthesis of ketones via organolithium addition to acid chloride using continuous flow chemistry.
Moon, S-Y.; Jung, S-H.; Kim, U B.; Kim, W-S. RSC Adv., 2015, 5, 79385-79390.
DOI: 10.1039/C5RA14890A | [pdf] | [preview]

Methodology
A Synthetic Approach to N-Aryl Carbamates via Copper-Catalyzed Chan–Lam Coupling at Room Temperature.
Moon, S-Y.1; Kim, U B.1; Sung, D.-B.; Kim, W-S. J. Org. Chem., 2015, 80(3), 1856–1865. (1 = Equal contribution)
DOI: 10.1021/jo502828r | [pdf] | [preview]

Graduate School (New Zealand)
 Total Synthesis
Total Synthesis of Chaetoquadrins H and I.
Kim, U B.; Dalebrook, A. F.; Furkert, D. P.; Brimble, M. A. Synlett. 2013, 24(6), 723-726.
DOI: 10.1055/s-0032-1318333 | [pdf] | [preview]

Total Synthesis
Total synthesis of Chaetoquadrins A–C.
Kim, U B.; Furkert, D. P.; Brimble, M. A. Org. Lett., 2013, 15, 658–661.
DOI: 10.1021/ol303482k | [pdf] | [preview]

Total Synthesis
Synthesis of (±) Wine Lactone and Its Analogues by a Diels–Alder Approach.
O'Connor, P. D.; Kim, U B.; Brimble, M. A. Eur. J. Org. Chem. 2009, 4405–4411.
DOI: 10.1002/ejoc.200900486 | [pdf] | [preview]

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For a Korean, hard copy of the CV, please click below: